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CBD – Frequently asked questions
CBD, an acronym for cannabidiol, is an essential component of medical marijuana. It is one of the two major active compounds present in the Cannabis sativa plant, the other being delta-9-tetrahydrocannabinol (THC). Both of these produce feelings of relaxation and calm, but the main difference is CBD is not psychoactive. It means CBD intake is not associated with a high, or potential for abuse or dependence. CBD imparts its effect on the body by influencing the CB1and CB2 receptors of the endocannabinoid system (ECS). The endocannabinoid system (ECS) normally helps in the regulation of certain functions such as appetite, sleep, mood, immune response, memory, fertility, and the perception of pleasure and pain; regardless of the CBD use. CB1 receptors are present in the central nervous system (CNS) and govern coordination, movement, appetite, pain, mood, and memory. CB2 receptors are primarily found in the peripheral nervous system (PNS) and regulate immune cell functions, including pain and inflammation. CBD can also modulate serotonin receptors, which explains its positive effects on anxiety, depression, and insomnia.
In most cases, CBD is well-tolerated; however, there is a slight chance of experiencing some unwanted effects. The risk of having a side effect is increased when it is contaminated with other compounds. The most common side effects that occur after taking CBD are dry mouth, diarrhoea, reduced appetite, fatigue, and low blood pressure. Though it is not euphoric, it can sometimes lead to light-headedness and drowsiness.
CBD can interact with certain drugs; it is recommended to consult your healthcare provider before you start using it. CBD interacts with other sedatives which results in additive effects and excessive inhibition of the receptors in the central nervous system. The sleep induced by CBD is calming and wake-inducing, but it is better to avoid the combined use of CBD and sleeping pills.
CBD provides a wide range of therapeutic advantages by interacting and affecting the endogenous regulatory systems of the body. However, its ability to inhibit cytochrome p450,  which metabolizes many drugs, produces complex drug interactions and adverse effects. Therefore, people who are using the following medications should not use CBD. · Steroids · Statins · Calcium channel blockers · Anti-histamine (anti-allergic) · Prokinetics (motility drugs) · Anti-HIV drugs · Immunomodulators · Benzodiazepines · Anti-arrhythmic · Beta-blockers · Proton pump inhibitors (reflux drugs) · Anti-diabetic
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